As we’ve discussed in previous posts, nitric oxide is a “crucial biological mediator” that helps the body in a dozen different ways—from sexual performance enhancement to easing arthritis to potentially preventing or reversing atherosclerosis. So scientists have been searching for ways to improve the delivery of nitric oxide to critical systems when needed. In their efforts they’ve discovered what they call nitric oxide donor drugs, logically enough, since their main purpose seems to be to help the body generate more nitric oxide and use it more effectively.
Just read about a new such drug, naproxcinod, they’ve tested in comparison with placebo and naproxen, which is a standard NSAID for arthritis. Looks promising for treating the hip pain of osteoarthritis. Having been a hip replacement patient—and having spent more than 10 months in twice-a-week therapy trying to recover semi-normal activity levels—I can vouch for what a great thing it would be to be able to relieve that pain and keep from having that terribly invasive surgery. But of course my real hope for future hip-and-knee-pain-sufferers is that researchers will find a way—they’re already saying it’s promising—to use stem cells to regenerate lost cartilage in our joints. The big issue with that is getting the stem cells to differentiate into the three needed types of cells for cartilage, including the “scaffolding” that has the powerful weight-bearing capabilities of our natural cartilage.
What an amazing thing is the human body. I hope I’m around long enough to see these studies result in actually saving someone from a brutal hip replacement operation.