All posts by Barbara Payne

Nanoparticles can attract contaminants–and purify radioactive milk?

The danger classification sign of radioactive ...
The danger classification sign of radioactive materials (Photo credit: Wikipedia)

When radioactive fallout was found to have contaminated some of Japan’s local food and drink after the 2011 tsunami battered a nuclear power plant in Fukushima, it inspired some scientists to look for ways to purify liquids. One researcher diverted his work on nanoparticles originally designed to “mine uranium from seawater or to decontaminate waterways.” He’s now adapting his work to make nanoparticles attach to a pellet that can decontaminate radioactive liquids.

The nanoparticles that coat the pellets are microscopic grains of materials called metal oxides. They absorb “a variety of radioactive materials such as uranium and strontium, as well as non-radioactive toxic elements such as lead and arsenic.” They attach tightly to the pellets and “will not detach into the liquid,” according to the researcher. Then the pellets are placed in a porous capsule and “would be too large to fall out.”

Sounds like a bug or animal trap that lets the creature in but won’t let it get out. Hmm. We’d have to place a great deal of trust in this invention to give our kids such “formerly” radioactive milk to drink. But then, that’s the kind of trust we put into a lot of what medicine prescribes (think: statins) and what manufacturers put in our homes or on our plates (think: GMO foods).

The technology has not yet gone commercial so you definitely won’t see boxes of “anti-radiation” pills in your local drug store any time soon. It’s a great idea, but let’s pray it will end up like the famed *backyard atomic bomb shelters of the 1950s–we don’t ever find out how well it works because we never have to use it.

* For those of you too young to remember, after the first atomic bombs were dropped on Japan to end WWII, the U.S. government had schools conducting air-raid drills in which kids hid under their desks and had citizens learning how to dig bomb shelters in their backyards.

Like a grade school desk or a foot of dirt would protect you from an atom bomb…

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Stem cells could revolutionize organ transplantation

Embryonic Stem Cells. (A) shows hESCs. (B) sho...
Embryonic Stem Cells. (A) shows hESCs. (B) shows neurons derived from hESCs. (Photo credit: Wikipedia)

Those on both sides of the fence hotly debate the advisability of legalizing the sale of donor organs. Meanwhile, a couple of exciting new developments in using stem cells in transplantation caught my eye recently—using stem cells to protect against organ rejection and a new way to study how they work once they’re put into the organ recipient’s body.

Cut down on immunosuppressants

A small new study suggests that some kidney transplant patients who receive bioengineered stem cells from their donors may not need anti-rejection drugs long term. Five of eight patients who received the stem cells in addition to the organ were able to stop taking immunosuppressants after one year, according to Science Translational Medicine. If they can replicate this in a bigger study, it could mean reducing fewer drugs for transplant patients and being able to use more donor organs for transplants. There are typically around 47,000 people a year waiting for a kidney and that wait can currently take years.

Learn how stem cells work for transplants

Looking into the process of using them, NIH researchers have developed a way to monitor how stem cells function once transplanted. The method uses magnetic resonance imaging (MRI) and consists of two FDA-approved drugs that can attach to cells and a third that is detectable by MRI. The technique is being tested in brain tumor patients who receive transplants of engineered neural stem cells, according to Molecular Imaging. The technique will help doctors understand how many of the cells they transplant actually reach the target organ, and so help them regulate how they administer the cells, plus how to adjust doses and timing.

Wouldn’t it be great if we didn’t have to resort to selling organs—which would likely turn out to produce another crop of heart-wrenching episodes of Law & Order (the original)?

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Hybrid NOSH aspirin pairs H2S with nitric oxide to fight cancer

You’ve heard of hybrid cars, which combine power sources—gasoline and an on-board rechargeable energy storage system (RESS). Now there’s a hybrid aspirin that combines acetylsalicylic acid, nitric oxide (NO) and hydrogen sulfide (H2S). They call it the “NOSH aspirin,” and they’re saying it can stop cancer cells from growing.

Generic regular strength enteric coated 325mg ...
Image via Wikipedia

Cancer-fighting properties of the new hybrid aspirin are reported in the ACS Medicinal Chemistry Letters. The same scientists had already developed a safer-on-the-stomach aspirin that used nitric oxide.

By adding hydrogen sulfide with its anti-inflammatory properties, the hope was that the aspirin would reduce the long-term inflammation that is thought to lead to abnormal cell growth and thereby contribute to a variety of cancers. Such long-term inflammation might come from infections or diseases such as HPV (can lead to cervical cancer) and hepatitis B (a precursor to liver cancer).

NO is important for a great many functions “in the gastrointestinal tract, including mucosal blood flow, maintenance of mucosal integrity, and maintenance of vascular tone,” according to the National Institutes of Health,

Scientists have for years been studying the role of hydrogen sulfide in the development of cancer prevention drugs. When they noted that cruciferous vegetables such as broccoli, watercress and Brussels sprouts naturally protect against stomach and colon cancers, they decided to mix

NO and H2S in the hope of coming up with dual benefits. Voila, the NOSH aspirin.

Laboratory tests on animals show the aspirin inhibits growth of breast, colon, pancreas, lung, prostate and some types of leukemia cancer cells without damaging normal cells. NOSH preparations were recorded as being 100,000 times more effective against cancer than regular aspirin.

 

Other studies have shown even regular aspirin offers a significant reduction of chances of hereditary cancers. But regular intake of aspirin carries a risk of gastrointestinal bleeding and in somecases Reye’s syndrome.

So it will probably come soon. Clinical trials will see whether the cost-benefit ratio of using NOSH aspirin for cancer prevention gets up to where it needs to be for human consumption.

 

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Way to grow brain cells called “game changer” for studying Parkinson’s

Parkinson's disease
Image via Wikipedia

Parkinson’s is one of those diseases that must be studied in human neurons because animal models that don’t have the parkin gene never develop the disease so they can’t be used. And of course we can’t just cut into people’s brains for scientific purposes.

Now, scientists have developed a way to grow donated human skin cells into brain cells that can show the parkin gene at work. This work may lead to being able to reverse this type (genetic mutation) of Parkinson’s, a type found in about one of every ten Parkinson’s patients.

The article doesn’t say, but I’m guessing this type of discovery has arisen directly out of stem cell research. One more utterly compelling reason to continue funding that work.

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Mouse studies say nanoparticle-delivered drugs can be targeted

dick mouse
Image via Wikipedia

Reports are all over the Internet about a recent study using nanoparticles as additions to vaccines that target lymph nodes. The study has found that, at least in mice, these nano-loaded treatments can boost antibody- and immune responses against lethal infections. The Duke University team that did the study says their loaded nanoparticles closely mimic the structure and actions of mast cells—those little guys that naturally help us fight infection. They say the fact that they can load the particles with different combinations of cytokines means they can steer the direction of the immune response.

Sounds very promising indeed. My first thought was, this is in mice. How well does mouse research translate into human treatments? First, I learned that the mouse has 99% of the same genes as we humans. Then, too, scientists already have a huge selection of sophisticated tools  for working with mice. Plus, the mouse’s tiny size makes it affordable for large studies.

Then I learned that lots of research studies conducted with mice have not translated at all well to humans. A global cross-discipline (academia, industry, clinical) group convened last year to discuss the whole mouse-as-model issue and came to some conclusions. The most significant of these, for our purposes here, seems to be that mice studies have been successfully translated mostly to validate drug targets and to determine safe and effective doses of combination treatments in humans. Read the entire (slightly windblown) mouse model conference report here.

Another example of successfully using nanoparticles as targeted carriers is in treating prostate cancer in mice. Tumors

Nanoparticle Characterization
Image by EMSL via Flickr

shrank significantly, and treated mice survived much longer than untreated, and longer, too, than even those treated with the same drug but not delivered with the targeted nano carrier. And in this study they aimed to have the targeted drugs bypass both healthy tissue and the immune system. It’s wonderful that such precision is possible.

But meanwhile, because I regularly research information about the very long time—often decades—it takes for asbestos exposure to show up as deadly disease in human beings, I continue to worry about the long-term effects of manufactured nanoparticles being injected into living creatures. I sincerely hope scientists are planning long-term followup studies of mice treated with nanoparticle-boosted drugs and vaccines. Before we head towards human clinical studies, let’s make sure the mice didn’t get saved to live another day and then die of complications from having nanomaterials delivered directly into their bodies.

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How dogs tell sickness – can technology help us learn?

nose to nose
Image by pixieclipx via Flickr

Dogs can smell seizures, low blood sugar and heart attacks, and doctors are working to see if they can be trained to detect other diseases such as cancer. A recent study suggests we humans may soon begin to emulate their powerful scenting abilities—with technology, of course.

New hope for early diagnosis comes from an electronic nose, a version of which is already in use in the food, wine and perfume industries. It generates a pattern, or “smell print”, in response to a given odor, then researchers analyze and compare that pattern with stored patterns. They’ve developed one that can tell from a person’s exhaled breath if that person has pneumonia. Now they’re studying the e-nose in the hope they can one day make it detect ashtma and some versions of lung cancer. A test of an e-nose has already been done to detect malignant pleural mesothelioma, a rare but aggressive form of lung cancer.

I X Key _ 59 Pr
Image by I X Key via Flickr

So that’s how they can keep producing winning smells in food, wine and perfume! And here I thought it was magic—the way I used to think that music composition was the most wonderfully mysterious art of all, because I had no idea how they did it until I studied music. I remember the article in Time magazine a few decades ago that contained a dozen gorgeous abstract paintings—and explained that they’d been generated by numerical equations plugged into a computer.  It blew my mind to realize that math and art were not only not radically different but were merely two different ways of looking at the same thing.

Even as we begin to discover more and more ways to heal the human body using the gentle tools of the universe such as stem cells, rather than violating the body with cutting, assaulting tools such as surgery and chemotherapy, we can take comfort, too, in the idea that many of the mysteries of the earth might one day be translatable to and from mathematical equations.

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Early palliative care improves end of life in lung cancer

When death is near, do lung cancer patients live longer with chemotherapy or with early palliative care? Patient

Of the three types of lung cancer, non-small cell lung cancer is the most common. Oncologists have been trained to treat it aggressively, including heavy use of chemotherapy.  Some researchers decided to test informal conclusions reached earlier that seemed to show that such aggressive use of chemo in the last stages of cancer improved survival.

Unlike previous looks at these alternatives, the current study was carefully designed, and it found conclusively that giving patients early palliative care—i.e., treating only to relieve symptoms rather than trying to cure the disease—along with standard oncology care, but excluding chemotherapy, actually does increase patient survival times. What’s more, it definitively improves quality of life during the last 60 days before death.

A part of that QOL improvement in the study came because, in stopping the aggressive treatment, doctors were not inadvertently leading patients to believe that such treatment might still potentially save their lives. The patients  better understood the truth of their situation.

I am glad to hear there is now scientific backing for this quieter end to life. It’s hard enough knowing you’re going to die, but even worse to have to meanwhile suffer the discomforts and indignity of having your body bombarded with and fighting the effects of poisonous chemicals. This is a time when you may want all your strength and clarity of mind to find closure with your loved ones and peace with the end of your life.

 

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Inhaled nitric oxide can help prevent stroke damage

PET image shows blood flow in the brain. Texts...
Blood flow in the brain - Image via Wikipedia

Stroke is the #3 killer in the U.S. and other industrialized countries. Plus, the death of brain cells as a result of a stroke can induce disability at one level or another across a critical range of human functions—speech, movement, thought processing, writing, etc.

Nitric oxide (NO) doesn’t normally affect blood flow in the brain. But now a few studies have shown a stroke can change that. Inhaling nitric oxide with an oxygen/air mix actually increases blood flow into areas of the brain where arterial blood was blocked during the stroke. They’ve confirmed this phenomenon in two studies in mice and one with large animals.

Another accomplishment for NO, this miraculous substance we produce in our bodies. Read a few more posts about  nitric oxide here.

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Too much salt not just bad for blood pressure

MIAMI, FL - SEPTEMBER 29:  In this photo illus...
Good source of potassium - Image by Getty Images via @daylife

We’ve all heard since we were young, if you have high blood pressure you have to  cut your salt. Now scientists have found more people with high salt levels are dying of cardiovascular and all other causes—when they also have low potassium levels.

Sodium is known to  raise blood pressure and stiffen arteries. Potassium activates nitric oxide, which relaxes arteries and combats high blood pressure. Sodium also interferes with the body’s ability to use nitric oxide. Read more at National Institutes of Health on sodium-potassium.

A poor ratio of salt to potassium is found with more deaths from cardiovascular causes and from all causes. It’s a question of balance, according to a recent study in the Archives of Internal Medicine put out by the Centers for Disease Control and Prevention.

And of course, the study does not say that the high-salt-low-potassium levels are what actually killed people—just that many deaths were associated with the poor ratio. Other causes could certainly be more directly responsible for the deaths they counted. Perhaps a reasonable conclusion we might make is that if you eat too much salt you might also be prone to make other less-than-ideal lifestyle and nutrition choices.  Geez, these days we can’t get away with anything…

?esky: Tonometr English: Automatic brachial sp...
Image via Wikipedia

But either way, folks with high blood pressure or congestive heart failure must carefully ration consumption of foods high in sodium–which includes almost anything you buy in packages or eat in restaurants—and eat lots of foods high in potassium. Thankfully there are dozens of tasty foods loaded with it, so most people don’t have to look to supplements. Like have a baked potato—one of the richest and best-tasting sources of potassium you can get. By the way, start gradually substituting no-fat yogurt for your sour cream. Then when you use just yogurt on your baked potato you get another boost to potassium along with other nutrition benefits.

Studies show that Americans get about 75% of their sodium from prepared foods and restaurant meals. I’ve personally found that if I eat mostly fresh foods and those I cook from scratch, I don’t have to totally avoid salting my food. So it may be that if you don’t get the gross overload of sodium from prepared foods, there’s room for enough salt to safely make your own cooked foods taste very good. Naturally, though, your doctor is the last word on all of this.

Have a happy, healthy new year—and eat some spinach in your scrambled eggs tomorrow to combat the potato chips and cheese in your NYE feast tonight…

 

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Nitric oxide eases altitude sickness–by genetic adaptation or Viagra-like drug

My sister and her husband recently had to cut short their vacation in the mountains of western U.S. They got extremely sick with altitude sickness. Scary.

viagra is a commercial produced medicine conta...
Image via Wikipedia

Well, apparently even 500 years of living at high altitudes is not enough time for humans to adapt so that their lungs work well enough to prevent altitude sicknesses. But Tibetans, who’ve been living at high altitudes for 25,000 years, and Bolivians who’ve also lived in the mountains for thousands of years have adapted so well that they completely avoid altitude sickness. Their lungs now automatically produce more nitric oxide than we plain dwellers, according to this article on CNN.com about how Tibetans and Viagra demonstrate the power of nitric oxide.

They don’t advise mountain climbers to run out and buy Viagra to solve the issue. The drug comes in big doses and only lasts “up to 4 hours,” but your lungs don’t need that much. More research will certainly be done to determine the magic combination and proper dosage that will work for high-altitude short-termers.

I love discovering new uses for this multi-talented substance that our bodies produce. Check out some interesting BioMedNews posts on nitric oxide.

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