The substance nitric oxide (NO), one of my favorite topics, is now known to be break-downable into components, one of which has one less electron. It’s known as NO(-) or HNO or nitroxyl, and researchers are finding some exciting new applications for it.
The other use for nitroxyl (HNO) involves its use in treating heart failure. Researchers normally write in very reserved terms about their discoveries, but the author of the passage below seems pretty excited about the implications of the research. Basically it’s saying that HNO donors can do things that regular NO donors cannot do and may be dramatically more useful in treating cardiovascular disease.
Thus, unlike NO*, HNO can target cardiac sarcoplasmic ryanodine receptors to increase myocardial contractility, can interact directly with thiols and is resistant to both scavenging by superoxide (*O2-) and tolerance development. HNO donors are protective in the setting of heart failure in which NO donors have minimal impact.
It’s cool to see this showing three of my favorite topics coming together: nitric oxide, nanotechnology and heart failure. But then, when all is said and done someday, everything in bioscience will undoubtedly coalesce in one way or another.
Blood clots can wreck quality of life and even kill by causing a stroke or a heart attack. But up ’til now doctors have been unable to predict when a clot might develop in a particular patient. Now nanotechnology is making possible a way to read signals in your urine that your body may be getting ready to produce one of these little clots with such destructive potential.
Good news is that the iron oxide particles used in the test have already been approved for use in humans, so the time to clinical trials shouldn’t be too prolonged. The test will be used to help people in emergency rooms who have symptoms that resemble those caused by a blood clot and also to monitor others at high-risk, such as those who fly a lot or who must spend a lot of time in bed after surgery.
I have a relative who suffered a stroke at a young age, so I know how terrifying it can be – and how it can degrade a person’s quality of life. The goal of the new test is to make it as easy as, “Pee on this stick and call me in the morning.” Imagine the sadness, fear and suffering that could potentially be averted.
Looking at how bioscience news affects business, higher education, government – and you and me